Vape devices have become increasingly popular over the years, with millions of people worldwide using them as an alternative to traditional tobacco products. One crucial aspect of vaping is the absorption rate of vape liquids, which affects the overall vaping experience. In this article, we’ll delve into the science behind vape liquid absorption rates, exploring the factors that influence them and the latest research in this area.

What is Vape Liquid Absorption?

Vape liquid absorption refers to the process by which the e-liquid is absorbed into the bloodstream through the lungs when vaping. This process involves several complex mechanisms, including evaporation, condensation, and solubilization. The rate at which vape liquids are absorbed can vary significantly depending on several factors, which we’ll discuss later.

Factors Affecting Vape Liquid Absorption Rates

  1. Nicotine Concentration: Nicotine is a highly soluble substance that plays a crucial role in vape liquid absorption. Higher nicotine concentrations can increase the absorption rate, as nicotine molecules are more readily absorbed into the bloodstream.
  2. PG/VG Ratio: The ratio of propylene glycol (PG) to vegetable glycerin (VG) in vape liquids can significantly impact absorption rates. PG is more easily absorbed than VG, so higher PG ratios can increase absorption rates.
  3. Temperature and Voltage: The temperature and voltage of the vape device can influence the rate of evaporation and subsequent absorption. Higher temperatures and voltages can increase the absorption rate.
  4. Device Design and Coil Type: The design of the vape device and coil type can affect the rate of evaporation and absorption. For example, sub-ohm coils can increase the absorption rate due to their larger surface area.
  5. User Behavior: User behavior, such as puff duration and frequency, can also impact absorption rates. Longer puff durations and more frequent puffs can increase the absorption rate.

The Role of Lipophilicity and Hydrophilicity

Lipophilicity (the ability of a substance to dissolve in lipids) and hydrophilicity (the ability of a substance to dissolve in water) play crucial roles in vape liquid absorption. Nicotine, being lipophilic, is more easily absorbed into the bloodstream through the lungs, while VG, being hydrophilic, is more soluble in water and takes longer to absorb.

Latest Research and Findings

Recent studies have shed light on the science behind vape liquid absorption rates. One study published in the Journal of Aerosol Medicine and Pulmonary Drug Delivery found that nicotine absorption rates were significantly higher with higher nicotine concentrations and PG ratios (1). Another study published in the European Respiratory Journal found that temperature and voltage significantly impacted vape liquid absorption rates (2).


Vape liquid absorption rates are influenced by a complex array of factors, including nicotine concentration, PG/VG ratio, temperature, voltage, device design, coil type, and user behavior. Understanding these factors is crucial for optimizing the vaping experience and minimizing potential health risks. Further research is needed to fully understand the science behind vape liquid absorption rates and to develop safer and more effective vape devices. Central Vapors